Several aspects of mitochondrial function, including respiratory complex activities and mitochondrial-dependent oxidative damage and apoptosis, are also induced by ethanol 26,100. Myocyte cytoskeletal structure 21, connexin channel communication, and desmosomal contacts are affected by ethanol, causing structural cell instability 105. Ethanol may induce changes in nuclear regulation of transcription with a dose-dependent translocation of NFkB…